Olfactory Dysfunction in Parkinson’s Disease, Its Functional and Neuroanatomical Correlates

Parkinson’s disease (PD) is known for its motor alterations, but the importance of non-motor symptoms (NMSs), such as olfactory dysfunction (OD), increasingly recognized. OD may manifest during prodromal period disease, even before appear. Therefore, it suggested that this symptom could be considered a marker PD. This article briefly describes PD, evolution knowledge about in prevalence NMS and role diagnosis PD progression, assessment olfaction patients with α-synuclein aggregates pathophysiology then some functional, morphological, histological alterations observed different structures related to system, epithelium, bulb, anterior nucleus, tract, piriform cortex, hippocampus, orbitofrontal amygdala. In addition, considering growing evidence suggests cerebellum also involved has been included work. Comprehending existing functional neuroanatomical relevant better understanding mechanisms behind neurodegenerative disorder.